In contrast, the mortality rate was lowest (4.4%) in patients with TIMI 3 flow.83ĭespite these important associations, there are a number of limitations of the TIMI classification system. Thrombolysis and clinical outcome.83 In the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) angiographic substudy, the mortality rate for patients with TIMI 2 flow (7.4%) was similar to the mortality rate for those with TIMI 0 or 1 flow (8.9%). Modified from Sheehan FH, Braunwald E, Canner P, et al: The effect of intravenous thrombolytic therapy on left ventricular function: A report on tissue-type plasminogen activator and streptokinase from the Thrombolysis in Myocardial Infarction (TIMI) Phase I Trial. Alternatively, contrast material clears from a segment distal to a stenosis noticeably more slowly than from a comparable segment not preceded by a significant stenosis.Ī small amount of contrast flows through the stenosis but fails to fully opacify the artery beyond. However, contrast enters the terminal segment perceptibly more slowly than more proximal segments. Contrast material clears as rapidly from the distal segment as from an uninvolved, more proximal segment.Ĭontrast material flows through the stenosis to opacify the terminal artery segment. ![]() TIMI Flow Grade Classificationģ (complete reperfusion) 2 (partial reperfusion)ġ (penetration with minimal perfusion) 0 (no perfusion)Īnterograde flow into the terminal coronary artery segment through a stenosis is as prompt as anterograde flow into a comparable segment proximal to the stenosis. Several throm-bolytic trials have identified an important relationship between 90-minute TIMI flow grade after The TIMI Flow Grade System is a valuable tool for assessing the efficacy of reperfusion strategies in patients with STEMI and for identifying patients at higher risk for an adverse outcome with acute coronary syndromes or undergoing PCI.
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